Cargo aircraft come in a variety of sizes and designs, depending on their intended use and the amount and type of cargo they are designed to carry. Some cargo aircraft are designed to carry palletized cargo, which can be easily loaded and unloaded using a pallet jack or forklift. Other cargo aircraft are designed to carry large, heavy items such as cars, machinery, or military equipment.

Many cargo aircraft are also designed to be converted between passenger and cargo configurations, allowing them to be used for both purposes depending on the needs of the airline or operator. Some cargo aircraft are even designed to be used in a hybrid configuration, with part of the aircraft used for passenger seating and the other part used for cargo.

The use of cargo aircraft has greatly impacted the global economy, allowing for the efficient and cost-effective transport of goods across long distances. The cargo industry has also led to the development of specialized equipment and infrastructure, such as cargo terminals and loading equipment, to support the handling and loading of cargo onto aircraft.